Hemostasis and Thrombosis

21st Annual NATA Symposium

21st Annual NATA Symposium, Athens 2020The 21st Annual NATA Symposium on Patient Blood Management, Haemostasis and Thrombosis will take place on April 23-24, 2020 in Athens, Greece.

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21st Annual Symposium General Information

Focused Update: European Society of Anesthesiology Guidelines on the Management of Severe Perioperative Bleeding

European Society of Anesthesiology (ESA) guidelines on the management of severe perioperative bleeding (POB) were published recently.

In a Nataonline Focused Update, Prof. Kozek-Langenecker, Department of Anesthesia and Intensive Care, Evangelical Hospital Vienna, Vienna, Austria, and first author of the article published in the European Journal of Anaesthesiology, provides an overview of the recommendations.

The basis of clinical questions covered in the ESA guidelines is wide, she explains. POB management is not restricted to procoagulant strategies in overt POB but also includes patient optimization before, during and after bleeding. A web-app summarizing the key messages of the guidelines is available on the ESA website.

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From the Literature

Aug 21, 2019

Published: May 2019

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Antibody-based ticagrelor reversal agent in healthy volunteers.
N Engl J Med 2019;308:1825-1833.

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NATA REVIEW:
Dual antiplatelet therapy (DAPT) is frequently used in patients with acute coronary syndrome, coronary stents,...
REVIEW by:
D. Faraoni

Published: Apr 2019

Connolly SJ, Crowther M, Eikelboom JW, et al.

Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors.
N Engl J Med 2019;380:1326-1335.

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NATA REVIEW:
Andexanet alfa, a recombinant inactive form of human factor Xa, was developed for reversal of factor Xa (FXa)...
REVIEW by:
J. H. Levy

Published: Feb 2019

Kuiper GJAJM, van Egmond LT, Henskens YMC, et al.

Shifts of transfusion demand in cardiac surgery after implementation of rotational thromboelastometry-guided transfusion protocols: analysis of the HEROES-CS observational, prospective open cohort database
J Cardiothorac Vasc Anesth 2019;33:307-317.

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NATA REVIEW:
In this study, Kuiper et al. compared outcome after cardiac surgery in terms of bleeding, rethoracotomies,...
REVIEW by:
H. B. Ravn

Published: Jan 2019

Curley A, Stanworth SJ, Willoughby K, et al.

Randomized trial of platelet-transfusion thresholds in neonates.
N Engl J Med 2019;380:242-251.

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NATA REVIEW:
In this multicentre trial, infants born at less than 34 weeks of gestation and in whom severe thrombocytopenia...
REVIEW by:
T. Haas

Published: Dec 2018

Krag M, Marker S, Perner A, et al.

Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU.
N Engl J Med 2018;379:2199-2208.

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NATA REVIEW:
This European multicentre trial randomised ICU patients to receive 40 mg of IV pantoprazole or placebo...
REVIEW by:
J. H. Levy

Published: Dec 2018

Goobie SM, Zurakowski D, Glotzbecker MP, et al.

Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial.
J Bone Joint Surg Am 2018;100:2024-2032.

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NATA REVIEW:
Posterior spinal fusion is a complex surgical procedure indicated to correct spinal deformation in idiopathic...
REVIEW by:
D. Faraoni