Anemia Effects and Management

Focused Update: On the Relative Safety of Intravenous Iron Formulations

Intravenous (IV) iron is an important therapeutic modality for anemia management. Seven IV iron formulations are available in the United States and/or Europe. In a Nataonline Focused Update, Dr. Michael Auerbach, Clinical Professor of Medicine, Georgetown University, Washington, DC, USA, reviews recent evidence on the safety of available IV iron formulations.

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News

Detection, Evaluation, and Management of Preoperative Anemia in the Elective Orthopedic Surgical Patient: NATA Guidelines

Preoperative Anemia Management AlgorithmPreoperative anemia in patients undergoing elective orthopedic surgery is associated with increased likelihood of blood transfusion as well as increased perioperative morbidity and mortality. A standardized approach for the detection, evaluation, and management of anaemia in this setting has been identified as an unmet medical need.

A multidisciplinary panel of physicians with expertise in orthopedic surgery, orthopedic anesthesia, hematology and epidemiology was convened by NATA with the aim of developing practice guidelines for the detection, evaluation and management of preoperative anaemia in elective orthopedic surgery.

The working group, chaired by Alice Maniatis (Greece) and Peter Earnshaw (UK), was made up of Lawrence Tim Goodnough (USA), Göran Benoni (Sweden), Photis Beris (Switzerland), Elvira Bisbe (Spain), Dean A. Fergusson (Canada), Hans Gombotz (Austria), Oliver Habler (Germany, Terri G. Monk (USA), Yves Ozier (France), Robert Slappendel (The Netherlands) and Marek Szpalski (Belgium).

NATA guidelines were published in the January 2011 issue of the British Journal of Anaesthesia. The article can be downloaded free of charge from the BJA website.

Click here to access open-access full article

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From the Literature

May 25, 2013

Published: Apr 2013

So-Osman C, Nelissen R, Brand R, et al.

The impact of a restrictive transfusion trigger on post-operative complication rate and well-being following elective orthopaedic surgery: a post-hoc analysis of a randomised study.
Blood Transfus 2013;11:289-295.

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NATA REVIEW:
So-Osman et al. undertook a post-hoc analysis of their previous randomized trial on transfusion triggers....
REVIEW by:
J.-F. Hardy

Published: Feb 2013

Bregman DB, Morris D, Koch TA, He A, Goodnough LT

Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia.
Am J Hematol 2013;88:97-101.

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NATA REVIEW:
Forty-four random patients with iron deficiency anemia (IDA; serum ferritin ...
REVIEW by:
M. Muñoz

Published: Feb 2013

Lawler PR, Filion KB, Dourian T, Atallah R, Garfinkle M, Eisenberg MJ

Anemia and mortality in acute coronary syndromes: A systematic review and meta-analysis.
Am Heart J 2013;165:143-153 e145.

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NATA REVIEW:
Patrick Lawler and colleagues have performed a systematic review of cohort studies and randomized clinical trials...
REVIEW by:
J. L. Carson

Published: Jan 2013

Gafter-Gvili A, Rozen-Zvi B, Vidal L, et al.

Intravenous iron supplementation for the treatment of chemotherapy-induced anaemia - systematic review and meta-analysis of randomised controlled trials.
Acta Oncol 2013;52:18-29.

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NATA REVIEW:
This is an extremely well conducted, difficult meta-analysis. The data were carefully scrutinized and a conservative...
REVIEW by:
M. Auerbach

Published: Dec 2012

Garrido-Martín P, Nassar-Mansur MI, de la Llana-Ducrós R, et al.

The effect of intravenous and oral iron administration on perioperative anaemia and transfusion requirements in patients undergoing elective cardiac surgery: a randomized clinical trial.
Interact Cardiovasc Thorac Surg 2012;15:1013-1018.

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NATA REVIEW:
This prospective randomized placebo-controlled study conducted in 159 patients reported that perioperative oral...
REVIEW by:
P. Van der Linden

Published: Nov 2012

Schoorl M, van der Gaag D, Bartels PC

Effects of iron supplementation on red blood cell hemoglobin content in pregnancy.
Hematol Rep 2012;4:e24.

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NATA REVIEW:
The authors present an interesting study evaluating the effectiveness of iron supplements in late pregnancy....
REVIEW by:
C. Breymann