From the Literature

Published: Aug 2015

Glund S, Stangier J, Schmohl M, et al.

Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial.
Lancet 2015;386:680-690.

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NATA REVIEW:
Dabigatran etexilate is a direct thrombin inhibitor increasingly used for stroke prevention in patients with...
REVIEW by:
D. Faraoni

Published: Aug 2015

Caldeira D, Rodrigues FB, Barra M, et al.

Non-vitamin K antagonist oral anticoagulants and major bleeding-related fatality in patients with atrial fibrillation and venous thromboembolism: a systematic review and meta-analysis.
Heart 2015;101:1204-1211.

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NATA REVIEW:
Non-vitamin K antagonist oral anticoagulants (NOACs) are alternatives to vitamin K antagonists (VKAs) for the...
REVIEW by:
F. Bonhomme

Published: Aug 2015

Butler CE, Noel S, Hibbs SP, et al.

Implementation of a clinical decision support system improves compliance with restrictive transfusion policies in hematology patients.
Transfusion 2015;55:1964-1971.

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NATA REVIEW:
The authors report the impact of a clinical decision support system at a single centre to improve transfusion...
REVIEW by:
L. T. Goodnough

Published: Jul 2015

Muñoz M, Gomez-Ramirez S, Kozek-Langeneker S, et al.

'Fit to fly': overcoming barriers to preoperative haemoglobin optimization in surgical patients.
Br J Anaesth 2015;115:15-24.

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NATA REVIEW:
This is a most interesting review on patient blood management (PBM) authored by experts in the field. The...
REVIEW by:
J.-F. Hardy

Published: Jul 2015

Curry N, Rourke C, Davenport R, et al.

Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial.
Br J Anaesth 2015;115:76-83.

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NATA REVIEW:
In this unblinded randomised controlled trial that enrolled 43 adult trauma patients at two major UK civilian...
REVIEW by:
S. R. Ostrowski

Published: Jul 2015

Parry-Jones AR, Di Napoli M, Goldstein JN, et al.

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.
Ann Neurol 2015;78:54-62.

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NATA REVIEW:
Intracerebral haemorrhage is the most dreaded complication of anticoagulant treatment with vitamin K antagonists....
REVIEW by:
M. Levi

Published: Jul 2015

Whiting P, Al M, Westwood M, et al.

Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis.
Health Technol Assess 2015;19:1-228.

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NATA REVIEW:
This study from the UK's Health and Technology Assessment group looked at all the available evidence on clinical...
REVIEW by:
D. Thomas

Published: Jul 2015

Barty RL, Gagliardi K, Owens W, et al.

A benchmarking program to reduce red blood cell outdating: implementation, evaluation, and a conceptual framework.
Transfusion 2015;55:1621-1627.

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NATA REVIEW:
Outdating of blood components is a matter of concern in transfusion medicine. In the present study, a benchmarking...
REVIEW by:
R. Moog

Published: Jul 2015

Clark NP, Witt DM, Davies LE, et al.

Bleeding, recurrent venous thromboembolism, and mortality risks during warfarin interruption for invasive procedures.
JAMA Intern Med 2015;175:1163-1168.

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NATA REVIEW:
Preoperative management of patients treated with vitamin K antagonists who require elective surgical procedures...
REVIEW by:
D. Faraoni

Published: Jun 2015

Novikova N, Hofmeyr GJ, Cluver C

Tranexamic acid for preventing postpartum haemorrhage.
Cochrane Database Syst Rev 2015;6:CD007872.

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NATA REVIEW:
This Cochrane review systematically reviewed all the RCTs on the use of tranexamic acid in postpartum haemorrhage....
REVIEW by:
B. J. Hunt

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